Histology of variants of urothelial carcinoma of the bladder: a Moroccan series of 39 cases

Background The variant of urothelial carcinoma (UCV) is a rare and aggressive histological entity; its therapeutic management remains debated. Methods Between January 2017 October 2019, 39 patients were diagnosed retrospectively with variant. aim this study was to analyze the clinico-pathological aspects these variants better understand invasive disease. Results In cases, 36 (92%) men 3 (8%) women; average age 62 years; 54% had ? cT3 stage clinical lymph node involvement in 28% 23% distant metastases, 36% treated RC by other 10% refused RC. No patient received neoadjuvant chemotherapy. Lymph 28.5%. two predominant types squamous micropapillary differentiation between operating piece bladder biopsy 28.5%, 30% 21.5% 13%, respectively. overall survival at 20 months 70 40% for (TURB alone or TURB an adjuvant), There no significant difference groups ( p = 0.27). Conclusion UCVs are heterogeneous tumors which increasingly identified due their distinct morphological characteristics variable prognosis. Therapeutic not favor cystectomy our study. However, prospective using larger cohort still necessary validate results.